Nuclear imaging potential and in vitro photodynamic activity of Boron subphthalocyanine on colon carcinoma cells
Makaleler > Tam Makale · 2020
Yazarlar: Fatma YURT, Tayfun Arslan, Zekeriya Bıyıklıoğlu, Ayca Tuncel, Derya Ozel, Kasim Ocakoglu
Journal of Drug Delivery Science and Technology, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2020, cilt 56, ss 101567-101567
DOI: 10.1016/j.jddst.2020.101567
Özet
Photodynamic therapy (PDT) has been a promising clinical agent in various types of cancer in recent years. In this study, in vitro nuclear imaging and PDT potential of Es-SubPc (Boron subphthalocyanine) were evaluated in colon adenocarcinoma cell line (HT-29) and human healthy lung fibroblast cell line (WI-38). For this purpose, the Es-SubPc was labeled with I-131 using the iodogen method under the optimum conditions resulting in labeled with high yield (98.9 +/- 1.2%). In addition, the uptake rate of I-131-Es-SubPc was determined in HT-29 and WI-38 cell lines. In comparison to the healthy cell line, the uptake of 131I-Es-SubPc was found to be 2-fold higher in the HT-29 cell line. For PDT studies, both cells were exposed to white light at 30-90 J/cm(2) in the presence of Es-SubPc. The results showed that Es-SubPc was a good PDT agent likely to be used in HT-29 cell line. As a result, Es-SubPc can be promising nuclear imaging and PDT agent for colon carcinoma.