Nicotine withdrawal in selectively bred high and low nicotine preferring rat lines
Articles > Article · 2015
Authors: Tanseli NESİL, Lütfiye KANIT, Muzeyyen UĞUR, Sakire POGUN
Pharmacology Biochemistry and Behavior, Journal Indexed in SCI Expanded, International, WoS, 2015, vol 131, pp 91-97
DOI: 10.1016/j.pbb.2015.02.009
Summary
Background: We have generated high- and low-nicotine preferring (high-NP, low-NP) rat lines using voluntary oral nicotine intake as the selection criterion. After nine generations, the estimated realized heritability for high intake was 0.26. The aim of the current study is to compare how nicotine withdrawal varies between these two lines. This new analysis would help elucidate if nicotine withdrawal and intake share common genetic mechanisms.