Effectiveness of adjunctive low-dose doxycycline therapy on clinical parameters and gingival crevicular fluid laminin-5 gamma 2 chain levels in chronic periodontitis
Makaleler > Tam Makale · 2004
Yazarlar: Gülnur EMİNGİL, FATMA GÜL ATİLLA, T SORSA, P SAVOLAINEN, H BAYLAS
JOURNAL OF PERIODONTOLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2004, cilt 75, ss 1387-1396
DOI: 10.1902/jop.2004.75.10.1387
Özet
Background: Laminin-5 (Ln-5) is involved in the apical migration of epithelial cells during the development of periodontal pockets. Low-dose doxycycline (LDD) can therapeutically modulate the host response with its non -antimicrobial properties. In the present randomized, double-blind, placebo-controlled, parallel arm study, the effectiveness of LDD in combination with non-surgical periodontal therapy on gingival crevicular fluid (GCF) Ln-5,gamma2 chain fragment levels and clinical parameters in patients with chronic periodontitis was examined over a 12-month period.