Synthesis and in vitro evaluation of <SUP>99m</SUP>Tc radiolabeled lapatinib (LPT) and its PLGA formulation
Makaleler > Tam Makale · 2024
Yazarlar: Sevki Goksun Gokulu, Kadriye Busra Karatay, Ahmet Bilgi, Cansu Kayas, Nuri YILDIRIM, Ayfer YURT KILÇAR, Fazilet Zumrut Biber Muftuler, Mustafa Cosan Terek, Levent Akman
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, SCI İndekslerine Giren Dergi, Uluslararası, Wos, 2024, cilt 333, ss 665-672
DOI: 10.1007/s10967-023-09292-7
Özet
Lapatinib-(LPT) is a dual tyrosine kinase inhibitor that has important effects on the targeted therapy of various tumours. The current study is aimed to use a novel tracer strategy including Technetium-99 m-(Tc-99m) radiolabeled LPT and its poly(lactic-co-glycolic acid)-(PLGA) encapsulated formulation-(LPT-PLGA). In vitro bioaffinity of the [Tc-99m]Tc-LPT and [Tc-99m]Tc-LPT-PLGA was evaluated by using cell culture methods on human breast adenocarcinoma (MDA-MB-231), cervix adenocarcinoma and human ovarian (MDAH-2774) cancer cell lines. Radiochemical yield were over 95% and both compounds were examined high incorporation values on HeLa and MDAH cell lines. Current results may contribute to develope as the encapculated agents including radiotracer.