Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures
Makaleler > Tam Makale · 2012
Yazarlar: Engin BOJNIK, Ezgi Turunc, Güliz ARMAGAN, Lütfiye KANIT, Sandor BENYHE, Ayfer YALÇIN, Anna BORSODI
EPILEPSY RESEARCH, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2012, cilt 99, ss 64-68
DOI: 10.1016/j.eplepsyres.2011.10.020
Özet
It has been known for centuries that exogenous cannabinoids, such as tetrahydrocannabinol have anticonvulsant activity. Recent studies have advanced our understanding of the endogenous cannabinoid system and renewed the interest in cannabinoids as a potential treatment for epilepsy. The endogenous cannabinoid system is rapidly activated after seizure activity but still little is known about the molecular mechanisms underlying the role of the cannabinoid system in epilepsy.