Magnesium and anti-phosphate treatment with bisphosphonates for Generalised Arterial Calcification of Infancy: a case report
Makaleler > Tam Makale · 2018
Yazarlar: Fatma Dursun, Tülay ÖZTÜRK ATASOY, Serçin Güven, Heves Kırmızıbekmez, Gülcan Seymen Karabulut, Sevinç Kalın, Betül Sözeri
Journal of Clinical Research in Pediatric Endocrinology, Uluslararası, Wos, 2018
DOI: 10.4274/jcrpe.0204
Özet
What is already known on this topic?Generalized arterial calcification of infancy (GACI) is a rare disease that is associated with a high mortality rate owing to the development of severe hypertension and cardiovascular complications.GACI can begin in utero during the third trimester, 50% of children with GACI present with well-developed large arterial calcifications within the first week of life.Although there is no definitive treatment, it is claimed that patients treated with bisphosphonates have better survival rates.In contrast, children not treated with bisphosphonates were also reported to have spontaneous regression of large arterial calcifications.Furthermore benefit has been shown from magnesium treatment in some experimental animal models. What does this study add?To date, there has been only a few experimental treatment for GACI patients other than bisphosphonates.The case presented here is of a patient who did not respond to bisphosphonates alone and then improved clinically after treatment with magnesium and anti-phosphate (calcium carbonate) with continued bisphosphonates therapy.