Penetration and release studies of positively and negatively charged nanoemulsions—Is there a benefit of the positive charge?
Makaleler > Tam Makale · 2012
Yazarlar: Yücel BAŞPINAR, Hans-Hubert Borchert
International Journal of Pharmaceutics, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2012, cilt 430, ss 247-252
DOI: 10.1016/j.ijpharm.2012.03.040
Özet
The surface of all tissues, including the stratum corneum, carries a negative charge. Following that fact it is assumed that a positively charged topical formulation could lead to an enhanced penetration because of an increased interaction with the negative charge of the membrane. The intention of this study is to prove an enhanced penetration of a positively charged nanoemulsion compared to a negatively charged nanoemulsion, both containing prednicarbate. The release and penetration of these nanoemulsions, produced with the high pressure homogenization method, were investigated. Regarding these results reveals that the release of the negatively charged formulation is higher compared to the positively charged nanoemulsion, while the penetration of the positively charged nanoemulsion is enhanced compared to the negatively charged formulation. The results of the investigated positively charged nanoemulsion containing prednicarbate show that its topical use could be advantageous for the therapy of atopic dermatitis, especially regarding phytosphingosine, which was responsible for the positive charge. (C) 2012 Elsevier B.V. All rights reserved.