The effect of leptin on adrenal glands in rats with streptozotocin-induced diabetes: An experimental study
Makaleler > Tam Makale · 2007
Yazarlar: Kemal Ergin, Hüseyin AKTUĞ, Hulki Başaloǧlu, Hatice Kübra Başaloǧlu, Mahmut Ilker Yilmaz, Mehmet Turgut
Analytical and Quantitative Cytology and Histology, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Scopus, 2007, cilt 29, ss 291-295
Özet
OBJECTIVE: To determine the cross-section area of adrenal medulla and the percentage of Ki-67 (a proliferation marker) of the adrenal gland in diabetic rats after leptin injection. STUDY DESIGN: Twenty-nine male Wistar rats were randomly divided into 3 groups: control (C) group (n = 9), diabetes mellitus (DM) group (n = 10) and leptin-injected diabetes mellitus (DM+L) group (n = 10). Experimental DM was induced by a single intraperitoneal dose of streptozotocin (40 mg/kg). After this, leptin (100 μg/kg) was injected subcutaneously for a period of 2 weeks in the diabetic group. RESULTS: An atrophy of adrenal medulla in the DM group was observed, and this atrophy returned to normal morphology after injection of leptin. In addition, an increase in the Ki-67 percentage was demonstrated in the zona reticularis layers in the DM+L group. CONCLUSION: Our study indicated that leptin stimulates the sympathoadrenal system and the androgen producing adrenal cortex in DM rats. © Science Printers and Publishers, Inc.