Cytosine-type nucleosides from marine-derived Streptomyces rochei 06CM016
Makaleler > Tam Makale · 2015
Yazarlar: Semiha Cetinel Aksoy, Ataç UZEL, Erdal Bedir
The Journal of Antibiotics, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2015, cilt 69, ss 51-56
DOI: 10.1038/ja.2015.72
Özet
Rocheicoside A (3), a nucleoside analog possessing a novel 5-(hydroxymethyl)-5-methylimidazolidin-4-one substructure, was isolated from marine-derived actinomycete Streptomyces rochei 06CM016, together with a new (4) and three known compounds. Structures of the new metabolites were elucidated by one-dimensional (H-1 and C-13) and 2D NMR (COSY, HMQC and HMBC) and HR-TOF-MS analyses. All the metabolites exhibited significant antimicrobial activity. A plausible mechanism was proposed for compound 3's formation from amicetin.