Two cases with hypereosinophilic syndrome shown with real-time PCR and responding well to imatinib treatment
Makaleler > Tam Makale · 2012
Yazarlar: Nur SELVİ GÜNEL, Burçin KAYMAZ, Handan Haydaroglu Sahin, Mustafa Pehlivan, Cagdas AKTAN, Aysegul DALMIZRAK, Ezgi INALPOLAT, Buket KOSOVA, Mehmet Yilmaz, Vahap Okan, Güray SAYDAM
Molecular Biology Reports, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2012, cilt 40, ss 1591-1597
DOI: 10.1007/s11033-012-2207-6
Özet
The aim of this work was to report two cases of hypereosinophilic syndrome (HES). FIP1L1-PDGFRA fusion was assessed with two protocols at RNA level. The fusion transcript was found positive at the RNA level with both PCR methods in two cases. In this study, the efficiency of imatinib treatment and a dramatic response in two HES cases with multisystemic involvement showing the characteristics of a chronic myeloproliferative disease were presented. Both cases showed complete responses confirming that imatinib mesylate treatment could be successful even in patients with advanced HES having myeloproliferative disease.