Synthesis of a theranostic agent: radioiodinated PEGylated PLGA-indocyanine capsules and in vitro determination of their bioaffinity on ovarian, cervical and breast cancer cells
Articles > Article · 2015
Authors: Levent AKMAN, Fazilet Zumrut Biber Muftuler, Ahmet BİLGİ, Ayfer YURT KILÇAR, Sevki Goksun GOKULU, Emin İlker MEDİNE, Mustafa Coşan TEREK
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, Journal Indexed in SCI Expanded, International, 2015, vol 308, pp 659-670
DOI: 10.1007/s10967-015-4472-z
Summary
The aim of current study is to synthesize a theranostic (multi-functional) agent, which is targeted on ovary, cervical and breast cancer types with diagnosis and treatment potential and to determine its bioaffinity by using in vitro methods. In conclusion; the designed compound (IPPP), which has fluorescence capability (from Indocyanine), encapsulated structure (with PEGylated PLGA), included an anticancer drug (Paclitaxel) for targeting and radionuclidic tracer (I-131) content for tracing, has bioaffinity and promise for diagnosis and therapy on ovarian, cervical and breast cancer cell lines.