Preparation, quality control and stability of 99mTc-cefuroxime axetil
Articles > Article · 2007
Authors: Fatma YURT, Kübra TOPALOĞLU, Perihan ÜNAK
Journal of Radioanalytical and Nuclear Chemistry, Journal Indexed in SCI Expanded, International, WoS, 2007, vol 275, pp 161-164
DOI: 10.1007/s10967-007-6999-0
Summary
Cefuroxime axetil, a cephalosporin antibiotic used to treat bacterial infections, was investigated to label with Tc-99m. Radiolabeling of cefuroxime axetil was carried out by using stannous chloride method. Effects of pH and stannous chloride amount on the radiolabeling yield were investigated. The radiochemical purity of Tc-99m-cefuroxime axetil was determined by thin layer radio chromatography (TLRC), electrophoresis and high performance liquid chromatography. The maximum radiolabeling yield was 98 +/- 1%.