Comparative transcriptome analysis provides insights into dorso-ventral color pattern formation of Holothuria edulis

Makaleler > Tam Makale · 2026

Yazarlar: JUNKI YAN, SHILIN LIU, LIBIN ZHANG, FANG SU, QIANWEN WU, Mustafa Tolga TOLON, Emel ÖZCAN GÖKÇEK, LILI XING

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY - PART D: GENOMICS AND PROTEOMICS, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2026, cilt 60, ss 1-9

DOI: 10.1016/j.cbd.2026.101979

Özet

<p><span style="color: rgb(31, 31, 31);">Animal&nbsp;body&nbsp;color&nbsp;patterns&nbsp;are&nbsp;highly&nbsp;diverse&nbsp;and&nbsp;play&nbsp;critical&nbsp;roles&nbsp;in&nbsp;camouflage,&nbsp;intraspecific&nbsp;communication,&nbsp;and&nbsp;environmental&nbsp;adaptation.&nbsp;</span><em style="color: rgb(31, 31, 31);">Holothuria&nbsp;edulis</em><span style="color: rgb(31, 31, 31);">,&nbsp;an&nbsp;important&nbsp;echinoderm&nbsp;inhabiting&nbsp;tropical&nbsp;waters,&nbsp;exhibits&nbsp;a&nbsp;typical&nbsp;dorsoventral&nbsp;dichromatism.&nbsp;This&nbsp;unique&nbsp;body&nbsp;color&nbsp;difference&nbsp;represents&nbsp;a&nbsp;key&nbsp;phenotypic&nbsp;trait&nbsp;for&nbsp;its&nbsp;habitat&nbsp;adaptation;&nbsp;however,&nbsp;the&nbsp;core&nbsp;differential&nbsp;genes&nbsp;regulating&nbsp;this&nbsp;trait&nbsp;remain&nbsp;to&nbsp;be&nbsp;elucidated.&nbsp;In&nbsp;this&nbsp;study,&nbsp;comparative&nbsp;transcriptome&nbsp;sequencing&nbsp;was&nbsp;performed&nbsp;on&nbsp;the&nbsp;dorsal&nbsp;and&nbsp;ventral&nbsp;body&nbsp;wall&nbsp;tissues&nbsp;of&nbsp;</span><em style="color: rgb(31, 31, 31);">H.&nbsp;edulis</em><span style="color: rgb(31, 31, 31);">,&nbsp;leading&nbsp;to&nbsp;the&nbsp;identification&nbsp;of&nbsp;a&nbsp;number&nbsp;of&nbsp;differentially&nbsp;expressed&nbsp;genes&nbsp;(DEGs),&nbsp;followed&nbsp;by&nbsp;GO&nbsp;functional&nbsp;annotation&nbsp;and&nbsp;KEGG&nbsp;pathway&nbsp;enrichment&nbsp;analysis.&nbsp;GO&nbsp;enrichment&nbsp;analysis&nbsp;indicated&nbsp;that&nbsp;the&nbsp;DEGs&nbsp;were&nbsp;significantly&nbsp;enriched&nbsp;in&nbsp;functional&nbsp;categories&nbsp;such&nbsp;as&nbsp;extracellular&nbsp;region,&nbsp;peptidase&nbsp;inhibitor&nbsp;activity,&nbsp;and&nbsp;tetrapyrrole&nbsp;binding.&nbsp;KEGG&nbsp;pathway&nbsp;analysis&nbsp;further&nbsp;revealed&nbsp;significant&nbsp;enrichment&nbsp;of&nbsp;protein&nbsp;digestion&nbsp;and&nbsp;absorption,&nbsp;the&nbsp;TNF&nbsp;signaling&nbsp;pathway,&nbsp;and&nbsp;cholesterol&nbsp;metabolism.&nbsp;Notably,&nbsp;the&nbsp;pigmentation-related&nbsp;gene&nbsp;FMO2&nbsp;was&nbsp;highly&nbsp;expressed&nbsp;in&nbsp;the&nbsp;dorsal&nbsp;body&nbsp;wall&nbsp;tissue,&nbsp;whereas&nbsp;cyp1a1,&nbsp;ZIC1,&nbsp;Slc7a11,&nbsp;WNT-1,&nbsp;and&nbsp;ADAMTS20&nbsp;were&nbsp;highly&nbsp;expressed&nbsp;in&nbsp;the&nbsp;ventral&nbsp;body&nbsp;wall&nbsp;tissue.&nbsp;This&nbsp;study&nbsp;identified&nbsp;DEGs&nbsp;and&nbsp;enriched&nbsp;pathways&nbsp;associated&nbsp;with&nbsp;dorsoventral&nbsp;body&nbsp;color&nbsp;differences&nbsp;in&nbsp;</span><em style="color: rgb(31, 31, 31);">H.&nbsp;edulis</em><span style="color: rgb(31, 31, 31);">,&nbsp;providing&nbsp;new&nbsp;insights&nbsp;into&nbsp;the&nbsp;molecular&nbsp;regulatory&nbsp;mechanisms&nbsp;underlying&nbsp;body&nbsp;color&nbsp;pattern&nbsp;formation.&nbsp;From&nbsp;the&nbsp;perspective&nbsp;of&nbsp;aquaculture&nbsp;applications,&nbsp;body&nbsp;color&nbsp;is&nbsp;one&nbsp;of&nbsp;the&nbsp;important&nbsp;traits&nbsp;affecting&nbsp;the&nbsp;quality&nbsp;and&nbsp;market&nbsp;value&nbsp;of&nbsp;sea&nbsp;cucumber&nbsp;products.&nbsp;Elucidating&nbsp;the&nbsp;molecular&nbsp;mechanisms&nbsp;of&nbsp;body&nbsp;color&nbsp;variation&nbsp;can&nbsp;provide&nbsp;a&nbsp;scientific&nbsp;basis&nbsp;for&nbsp;molecular&nbsp;marker-assisted&nbsp;breeding&nbsp;of&nbsp;superior&nbsp;sea&nbsp;cucumber&nbsp;variety.</span></p>

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