Sepsis Kaynaklı Deneysel Sıçan Böbrek Hasarı Modeli Üzerine Oksitosin Etkisi: Histolojik ve Biyokimyasal Bir Çalışma
Makaleler > Tam Makale · 2017
Yazarlar: TÜRKER ÇAVUŞOĞLU, YUSUF SAVRAN, Yiğit UYANIKGİL, KANAT GÜLLE, AHMET ÇAĞDAŞ ACARA, GÜRKAN YİĞİTTÜRK, KUBİLAY DOĞAN KILIÇ, Emel Öykü ÇETİN UYANIKGİL, AYFER MERAL, OYTUN ERBAŞ
SDÜ Sağlık Bilimleri Dergisi, Diğer Kurumların Hakemli Dergileri, Uluslararası, IM: Index Medicus , 2017, cilt 9, ss 1-1
Özet
We aimed to investigate the therapeutic role of Oxytocin (OT) in sepsis induced rats and its effects on kidneys. Sepsis was induced in 24 of them by cecal ligation-perforation (CLP) method. One of the groups of CLP did not recieve any treatment while either saline 1 ml/kg or OT 0.4 mg/kg was applied intraperitoneally to the other groups within the first hour of surgery. 8 rats were sham-operated and 8 rats were spared as control group. Plasma TNF-α, CRP, MDA levels, total antioxidant capacity (TAC), creatinine level and peripheral leukocyte (WBC) counts were measured. TNF-α, CRP, MDA levels and WBC counts were significantly increased in CLP and CLP-saline groups, on the contrary they are decreased in CLP-OT group. Histopathologically loss of brush border, tubular dilatation and mononuclear cell infiltration was significantly decreased in CLP-OT group but there was no significant difference in erytrocyte extravasation and cast formation when compared to CLP and CLP-saline groups. Our results indicate that OT may have a therapeutic value in limiting sepsis induced inflammation and organ damage.