Amanicadol, a Pimarane-type Diterpene from Phlomis amanica Vierch.
Makaleler > Tam Makale · 2006
Yazarlar: Funda N. Yalçın, Tayfun Ersöz, Erdal Bedir, Ali A. Dönmez, Michael Stavri, Mire Zloh, Simon Gibbons, İhsan Çaliş
Zeitschrift für Naturforschung B, Uluslararası, Wos, 2006, cilt 61, ss 1433-1436
Özet
Fractionation of the methanol extract of Phlomis amanica resulted in the isolation of a new pimarane type diterpene, amanicadol (1), together with the known glycosides lamiide, verbascoside (= acteoside), syringaresinol-4-O-β -glucoside, liriodendrin, syringin, and a caffeic acid ester, chlorogenic acid. The structure of the new compound was established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation. Molecular modeling studies on 1 were conducted and showed that it exhibited low conformational flexibility. Additionally, NMR chemical shifts were calculated for 1 in vacuo, and calculated values were in very close agreement with those found experimentally.