Evaluation of the miRNA profiling and effectiveness of the propolis on B-cell acute lymphoblastic leukemia cell line
Makaleler > Tam Makale · 2016
Yazarlar: Ugur Cem Yilmaz, BAKİYE GÖKER BAĞCA, Emin KARACA, Asude DURMAZ, Mehmet Burak DURMAZ, Ayça AYKUT, Hüsniye KAYALAR, Çığır BİRAY AVCI, Sunde YILMAZ SÜSLÜER, Cumhur GÜNDÜZ, Muhsin Özgür ÇOĞULU
Biomedicine & Pharmacotherapy, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2016, cilt 84, ss 1266-1273
DOI: 10.1016/j.biopha.2016.10.056
Özet
Acute lymphoblastic leukemia (ALL) is one of the most frequent causes of death from cancer. Since the discovery of chemotherapeutic agents, ALL has become a model for improvement of survival. In parallel to this, serious side effects were observed and new natural therapeutic options has been discussed. One of these substances is called propolis which is a resinous substance gathered by honeybees. In the molecular era, miRNAs have been shown to play crucial roles in the development of many clinical conditions. The aim of this study is to evaluate the effect of Aydin propolis on 81 human miRNA activity in CCRF-SB leukemia cell line. Apoptotic effects of propolis on cell lines were also evaluated and apoptosis were found to be induced 1.5 fold in B-cell leukemia cells. The expression of 63 miRNAs (46 miRNAs were downregulated, 19 miRNAs were upregulated) in propolis treated leukemia cells have changed significantly (p < 0.05).