Risk factors for a poor hematopoietic stem cell mobilization
Makaleler > Tam Makale · 2013
Yazarlar: Ayhan DÖNMEZ, Fergun Yilmaz, Emine Nihal METE GÖKMEN, Murat TOMBULOĞLU
Transfusion and Apheresis Science, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2013, cilt 49, ss 485-488
DOI: 10.1016/j.transci.2013.04.040
Özet
Poor mobilization is an important problem in autologous stem cell transplantation. We retrospectively reviewed the data of 165 mobilized patients to identify possible risk factors for a poor stem cell mobilization. 27 patients (16.4%) were categorized as poorly mobilized. The poor mobilization ratio differed according to diagnosis (lymphoma: 25.4%, acute leukemia: 15.4%, amyloidosis: 14.3%, and multiple myeloma: 9.6%). Being diagnosed as lymphoma (odds ratio [OR] = 6.02, p = 0.001), advanced age (OR = 1.05, p = 0.007) and increased weight (OR = 1.03, p = 0.03) were found as possible risk factors. Being diagnosed as lymphoma was shown to be the most important risk factor for a poor mobilization. Leukapheresis staff should be aware of the increased risk of a poor mobilization in lymphoma patients and remobilization methods should be considered from the beginning. (C) 2013 Elsevier Ltd. All rights reserved.