Propolis Extract Regulates microRNA Expression in Glioblastoma and Brain Cancer Stem Cells.
Makaleler > Tam Makale · 2022
Yazarlar: Ugur C Yilmaz, BAKİYE GÖKER BAĞCA, Emin KARACA, Mehmet Burak DURMAZ, Burak Durmaz, Ayça AYKUT, Hüsniye KAYALAR, Çığır BİRAY AVCI, Sunde Y Susluer, Erhan Pariltay, Cumhur GÜNDÜZ, Muhsin Özgür ÇOĞULU
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2022, cilt 22, ss 378-389
DOI: 10.2174/1871520621666210504082528
Özet
Background: Grade IV gliomas are classified as glioblastoma (GBM), which is the most malignant brain cancer type. Various genetic and epigenetic mechanisms play a role in the initiation and progression of GBM. MicroRNAs (miRNAs) are small, non-coding RNA molecules that belong to the main epigenetic regulatory RNA class that plays different roles in either physiological or pathological conditions, including GBM pathogenesis regulating expression levels of the target genes. Brain Cancer Stem Cells (BCSCs) are responsible for poor prognosis, including therapy resistance and relapse. Epigenetic regulation mediated by miRNAs is also a critical component of BCSC self renewal and differentiation properties. Propolis is a resinous substance collected by honey bees from various plant sources. The flavonoid content of propolis varies depending on the collection region and the extraction method. Although there are studies that include the effects of different originated-propolis on the miRNA expression levels of the glioblastoma cells, the impact on the BCSCs has not been studied yet.