Gemcitabine hydrochloride microspheres used for intravesical treatment of superficial bladder cancer: a comprehensive in vitro/ex vivo/in vivo evaluation
Makaleler > Tam Makale · 2018
Yazarlar: Sinem Yaprak KARAVANA, Zeynep Ay Senyigit, ÇAĞRI ÇALIŞKAN, Gülnur SEVİN, Derya Ilem Ozdemir, Yalcin Erzurumlu, Sait ŞEN, ESRA BALOĞLU
DRUG DESIGN DEVELOPMENT AND THERAPY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2018, cilt 12, ss 1959-1975
DOI: 10.2147/dddt.si64704
Özet
Introduction: Bladder cancer is responsible for more than 130,000 deaths annually worldwide. Intravesical delivery of chemotherapeutic agents provides effective drug localization to the target area to reduce toxicity and increase efficacy. This study aimed to develop ail intravesical delivery system of gemcitabine HC1 (Gem-HCl) to provide a sustained-release profile, to prolong residence time, and to enhance its efficiency in the treatment of bladder cancer.