Does hiatus hernia have a detrimental impact on survival in IPF?
Conference paper > Summary Text
Authors: Nesrin Mogulkoc Bishop, Akın Cinkooglu, Omer Faruk Dadas, Zehra Nur Töreyin, Martina Koziar Vasakova
Idiopathic interstitial pneumonias, , , International, Summary Text, pp PA5089-PA5089
DOI: 10.1183/13993003.congress-2025.pa5089
Summary
Background: This study investigates the impact of hiatus hernia (HH) on survival in patients with idiopathic pulmonary fibrosis (IPF). Methods: Utilizing data from the EMPIRE Türkiye cohort, a descriptive analysis employed chi-squared tests, while survival was assessed via Kaplan-Meier and Cox regression methods. Results: The cohort included 1059 IPF patients (74.8% male, mean age 67 years; 25.2% female, mean age 68 years). BMI data were available for 1037patients: 16 underweight, 241 healthy, 467 overweight, and 313 obese. Baseline HRCT identified HH in 207 patients (19.5%), with 89 (8.4%) symptomatic for reflux. Among 906 patients with known PPI usage, 461 (51%) were on PPIs, with no correlation between HH and PPI use. A total of 767 patients (71.4%) received antifibrotic therapy. The mean follow-up duration was 44.5 months (range 0 to 199 months) and the median survival was 36 months. During follow-up, 677 patients (63.9%) died, including 530 males (66.9%) and 147 females (55.1%). Male gender was linked to a 50.3% increased risk of death (p<0.001). Each additional year of age at baseline correlated with a 2.3% rise in mortality risk (p<0.001). Higher BMI was associated with longer survival (4.2% increase per unit BMI, p<0.001), while antifibrotic therapy was also linked to improved survival (p<0.001; HR=0.714). Importantly, HH presence did not impact survival (p=0.37). Conclusion: Established mortality risk factors, including male gender and age, were confirmed, whereas the presence of hiatus hernia, as determined radiologically, did not affect survival outcomes in IPF patients.