The role of mean platelet volume in the early detection of acute bronchiolitis: A prospective study
Makaleler > Tam Makale · 2018
Yazarlar: Şule GÖKÇE, Nuri Zafer KURUGÖL, Aslı SUNER KARAKÜLAH
The Clinical Respiratory Journal, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2018, cilt 12, ss 2513-2518
DOI: 10.1111/crj.12947
Özet
INTRODUCTION AND OBJECTIVE: Acute bronchiolitis might be associated with morbidity and mortality in infants. The aim of this study was to evaluate the role of mean platelet volume (MPV) in the prediction of acute bronchiolitis. METHOD: One hundred and eighty-four of these infants were diagnosed with acute bronchiolitis and 100 were healthy children. The ability of MPV, C-reactive protein (CRP), white blood cell (WBC) count, and lymphocyte values to predict all bronchiolitis groups and the control group was examined by receiver operating characteristic (ROC) curve and their respective areas under the curves (AUC) with 95% confidence intervals. RESULTS: Patients with acute bronchiolitis had higher MPVs than their healthy counterparts (P < 0.001). However, there was no difference statistically significant in MPVs among all bronchiolitis groups (P = 0.239). ROC curve analysis suggested that MPV level cut-off point for making the prediction of acute bronchiolitis was 6.0 fL, with a sensitivity and specificity of 90% and 28%, respectively. Our results clearly indicated that AUCs for the MPV, CRP, WBC, and lymphocyte were statistically significant for bronchiolitis groups versus the control group. However, AUC values for MPV were the lowest. CONCLUSIONS: These findings suggest that the MPV might be a predictive value for the diagnosis of acute bronchiolitis. However, the predictive capacity of the CRP is better than that of others. Observational studies with a larger group to evaluate the clinical significance of MPV are necessary to predict acute bronchiolitis.