P53 protein expression in eccrine poroma and porocarcinoma
Makaleler > Tam Makale · 2001
Yazarlar: Taner AKALIN, Sait ŞEN, AYLA YÜCETÜRK, GÜLŞEN KANDİLOĞLU
AMERICAN JOURNAL OF DERMATOPATHOLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2001, cilt 23, ss 402-406
DOI: 10.1097/00000372-200110000-00003
Özet
The role of p53 mutation has been shown in different human malignancies, including various skin cancers. In this study, we examined p53 protein expression in 25 eccrine poromas and 11 porocarcinomas by immunohistochemistry. P53 expression was observed in 88% (22 of 25) of eccrine poromas and 73% (8 of 11) of porocarcinomas. In eccrine poromas, percentage of cells reactive for p53 was less than 5% (low expresser) in 6 cases, 5 to 50% (moderate expresser) in 14 and greater than 50% (high expresser) in 2 cases. In terms of intensity, 13 cases showed weak staining, 8 moderate, and 1 case showed strong reactivity. On the other hand, 2 cases of porocarcinoma were low expresser, 2 were moderate and 4 were high expresser. All of the high expressers had also strong staining.