Granulocyte colony-stimulating factor provides protection against cardiovascular autonomic neuropathy in streptozotocin-induced diabetes in rats
Makaleler > Tam Makale · 2015
Yazarlar: Oytun Erbas, Volkan Solmaz, Dilek TAŞKIRAN
Diabetes Research and Clinical Practice, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2015, cilt 107, ss 377-383
DOI: 10.1016/j.diabres.2014.12.018
Özet
Aims: Cardiovascular autonomic neuropathy (CAN) is a relatively common and detrimental complication of diabetes mellitus (DM). Dysregulation of neuropeptides, such as calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP), are thought to play significant roles in diabetes-related cardiovascular disease. Accumulating evidence indicates the neuroprotective effects of granulocyte-colony stimulating factor (G-CSF) in different neurological disorders. The purpose of the study is to investigate the role of CGRP and VIP and possible effects of G-CSF on CAN in type I DM model in rats.