Matrix metalloproteinases (MMP-8 and-9) and neutrophil elastase in gingival crevicular fluid of cyclosporin-treated patients
Articles > Article · 2001
Authors: FATMA GÜL ATİLLA, T Sorsa, H Ronka, Gülnur EMİNGİL
JOURNAL OF PERIODONTOLOGY, Journal Indexed in SCI Expanded, International, 2001, vol 72, pp 354-360
DOI: 10.1902/jop.2001.72.3.354
Summary
Background: Gingival overgrowth (GO) is one of the most important side effects of cyclosporin A (CsA) medication, but its pathogenesis is not completely understood. The aim of this study was to identify and compare collagenase-2 (MMP-8), gelatinase-B (MMP-9), and neutrophil (PMN)-elastase levels in gingival crevicular fluid (GCF) from 15 renal transplant patients receiving CsA therapy and exhibiting CsA GO, 14 patients with gingivitis, and 10 periodontally healthy subjects.