Collagen/physiologically clotted fibrin-based nanobioscaffold supported with silver nanoparticles: A novel approach
Articles > Article · 2022
Authors: Rethinam Senthil, Serdar Batıkan KAVUKCU, Thangavelu Lakshmi, Turkmen Gulsah, Adiguzel Zengin Arife Candas
The International Journal of Artificial Organs, Journal Indexed in SCI Expanded, International, WoS, 2022, vol 45, pp 1021-1027
DOI: 10.1177/03913988221119529
Summary
PURPOSE: In this work, a blend of collagen, physiologically clotted fibrin (PCF), and silver nanoparticles (AgNPs) is used to develop a nanobioscaffold (NBS), for their possible application in wound dressing materials. METHODS: The prepared NBS were evaluated using physicochemical, mechanical, and antibacterial properties. The NBS cell viability was demonstrated in a biocompatibility study using the human keratinocyte cell line (HaCaT). RESULTS: The results demonstrated that the NBS had excellent tensile strength (22.15 ± 0.05 MPa), elongation at break (13.32 ± 0.09%), and water absorption (97.51 ± 0.08). The in-vitro study demonstrated its biocompatible nature. NBS exhibited significant antibacterial activity against the Gram-negative and Gram-positive bacteria. CONCLUSION: The NBS with required mechanical strength, antibacterial activity, and biocompatibility may be tested as a wound material in rats after getting the necessary approval.