Triterpene Glycosides fromAstragalus angustifolius
Articles > Article · 2012
Authors: Derya GÜLCEMAL, Milena MASULLO, ERDAL BEDİR, Michela FESTA, Tamer KARAYILDIRIM, Özgen ALANKUŞ, Sonia PIACENTE
Planta Medica, Journal Indexed in SCI Expanded, International, WoS, 2012, vol 78, pp 720-729
Summary
Six new cycloartane-type (1- 6) and four new oleanane-type (7- 10) triterpene glycosides were isolated from Astragalus angustifolius Lam., together with five known triterpene glycosides. Their structures were established by the extensive use of 1D and 2D-NMR experiments along with ESIMS and HRMS analysis. Compounds 1- 3 are glycosides of cycloastragenol, while compounds 4- 6 show the C-24 epimer of cycloastragenol as aglycone, encountered for the first time in nature. All compounds were evaluated for their antiproliferative activity in Hela, H-446, HT-29, and U937 cell lines. Only compound 8 displayed a weak activity with IC (50) values of 36 and 50 µM against Hela and HT-29 cell lines, respectively.