Antioxidant activity of indole-based melatonin analogues in erythrocytes and their voltammetric characterization
Makaleler > Tam Makale · 2012
Yazarlar: Sibel Suzen, Betul Tekiner-Gulbas, Hanif Shirinzadeh, Duysal Uslu, Hande GÜRER ORHAN, Mehmet Gumustas, Sibel Aysil Ozkan
Journal of Enzyme Inhibition and Medicinal Chemistry, SCI İndekslerine Giren Dergi, Uluslararası, Wos, 2012, cilt 28, ss 1143-1155
DOI: 10.3109/14756366.2012.717223
Özet
Melatonin (MLT) is a strong free-radical scavenger, which protects the body from the effects of oxidants. In recent years, MLT have been described resulting in much attention in the development of synthetic compounds possessing. As a part of our ongoing study a series of indole-based MLT analogue hydrazide/hydrazone derivatives were synthesized, characterized and in vitro antioxidant activity was investigated by evaluating their reducing effect against oxidation of a redox sensitive fluorescent probe. Membrane stabilizing effect of all compounds was also investigated by lactate dehydrogenase leakage assay. Furthermore voltammetric methods have been applied to the synthesized compounds to characterize oxidation potentials to get insight into their metabolism owing to the oxidation mechanisms taking place at the electrode and in the body share similar principles.