Immunohistochemical Analysis of Inducible and Endothelial Forms of Nitric Oxide Synthase in Cyclosporin A-Induced Gingival Overgrowth
Makaleler > Tam Makale · 2009
Yazarlar: Ali GÜRKAN, Gülnur EMİNGİL, Guelperi OEKTEM, Nur SELVİ GÜNEL, Beral AFACAN, Tunc ILGENLI, Hueseyin TOEZ, Guel Atilla
JOURNAL OF PERIODONTOLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2009, cilt 80, ss 1638-1647
Özet
Background: The contribution of nitric oxide (NO) to immune response and matrix degradation in the periodontal environment suggests a role for NO and NO-synthase (NOS) activity in the pathogenesis of cyclosporin A (CsA) -induced gingival overgrowth (GO). However, current knowledge on this topic is limited to experimental animal studies. The present study was undertaken on the basis of a hypothesis whether altered nitrite/nitrate levels in gingival crevicular fluid (GCF) and endothelial NOS (eNOS) and inducible NOS (iNOS) immunoreactivity in gingiva of CsA-treated patients contribute to the pathogenesis of CsA-induced GO.