A New Concept in Treatment of Burn Injury
Makaleler > Tam Makale · 2011
Yazarlar: Serife Simsek, Halil Ibrahim Canter, Ersoy Konas, Petek Korkusuz, Devrim Demir, Filiz Oner, Ibrahim Unsal, Mehmet Emin Mavili
Annals of Plastic Surgery, Uluslararası, Wos, 2011, cilt 67, ss 583-588
DOI: 10.1097/sap.0b013e31822af865
Özet
OBJECTIVE: The aim of the study is to investigate the effectiveness of the controlled slow-release granulocyte-monocyte colony-stimulating factor (GM-CSF) system in burn wound healing. MATERIAL AND METHODS: In vivo effect of controlled slow-release GM-CSF from chitosan gel on burn wound healing was evaluated on 18 Wistar-Albino rats, weighing between 250 and 300 g. They were randomly divided into 3 groups; (1) burned only group (n = 6), (2) burned + chitosan group (n = 6), (3) burned + chitosan + GM-CSF group (n = 6). Wound area was measured macroscopically. Hematoxylin and eosin and Masson's trichrome stained sections were evaluated for wound healing and tissue response to the polymer. RESULTS: The best healing process was observed with the controlled slow-release GM-CSF-applied group (group 3) in which the wound area was significantly narrowed. CONCLUSION: The study demonstrated the positive contribution of the single-dose controlled slow-release GM-CSF from chitosan gel on burn wound healing.