Benzodiazepine Derivatives from Marine-Derived Streptomyces cacaoi 14CM034
Articles > Article · 2021
Authors: Semiha Cetinel Aksoy, MELİS KÜÇÜKSOLAK, Ataç UZEL, ERDAL BEDİR
Records of Natural Products, Journal Indexed in SCI Expanded, International, WoS, 2021, vol 15, pp 602-607
DOI: 10.25135/rnp.203.20.08.1766
Summary
7-methoxy-8-hydroxy cycloanthranilylproline (2), a new natural product with pyrrolobenzodiazepine (PBD) framework, was isolated from marine-derived actinobacterium Streptomyces cacaoi 14CM034, together with cycloanthranilylproline (1). Structural elucidation of the compounds was based on FTIR, 1D- (1H and 13C NMR), 2D-NMR (COSY, HMBC and NOESY) and HR-MS analyses. Compounds 1 and 2 exhibited notable antimicrobial activity. The presence of PBD derivatives in S. cacaoi was first demonstrated with this study.