Effect of valsartan versus lisinopril on peritoneal sclerosis in rats
Articles > Article · 2005
Authors: Soner DUMAN, Sait ŞEN, C DUMAN, DG OREOPOULOS
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, Journal Indexed in SCI Expanded, International, 2005, vol 28, pp 156-163
Summary
Background: Peritoneal sclerosis (PS) is one of the most serious causes of failure in long-term peritoneal dialysis. Angiotensin II is known to promote fibrosis and inflammation in various tissues. We previously showed that ACE inhibitors (ACEIs) have beneficial effects on hypertonic PD solutions (3.86% PD) induced peritoneal alterations. The aim of this study is to compare the effects of an ACEI and a receptor blocker on peritoneal alterations induced by hypertonic PD solutions in rats.