The association between progression of carotid artery intima-media thickness and cardiovascular events in peritoneal dialysis patients
Makaleler > Tam Makale · 2013
Yazarlar: Meltem SEZİŞ, Mehmet Nuri Turan, Meltem Sezis Demirci, Gülay Asci, Mustafa Yaprak, Ebru Sevinç Ok, Aygül ÇELTİK, Süha Süreyya Ozbek, Hüseyin Toz, Fehmi Akcicek, Mehmet Ozkahya, Ercan OK
Turkish Nephrology, Dialysis and Transplantation Journal, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2013, cilt 22, ss 238-244
DOI: 10.5262/tndt.2013.1003.02
Özet
OBJECTIVE: Measurement of carotid artery intima-media thickness (CA-IMT) is directly associated with cardiovascular (CV) outcomes. We retrospectively investigated the impact of CA-IMT progression on new CV events in patients on peritoneal dialysis (PD). MATERIAL and METHODS: All PD patients who have been followed in our unit (n=163) were screened. The patients who had no CA-IMT were excluded. Ninety-six patients who had baseline CAIMT measurement were included. Fifty-two patients had second CA-IMT measurement. Fatal and nonfatal CV events were screened from patients' charts. RESULTS: At baseline, mean CA-IMT was 0.62-0.16 mm (median 0.60 mm). In patients treated with PD more than 2 years, CV event rate was higher in patients with high CA-IMT (>0.60 mm) compared to the patients with low CA-IMT at baseline (22.2% versus 4.2%, p=0.041). In patients who had second CA-IMT measurement, mean CA-IMT increased from 0.62-0.17 mm to 0.66-0.17 mm (p=0.002). In ROC analysis, best cut-off value of CA-IMT progression was 0.0062 mm/month for prediction of CV events (AUC 0.752-0.066, p=0.046). When patients were grouped according to this cut-off value, CV event rate was higher in patients showed CA-IMT progression above 0.0062 mm/month (33.3% versus 2.7%, p=0.001). In Cox-regression analysis, progression of CA-IMT more than 0.0062 mm/month was only predictor for new CV events (ExpB=14.57, p=0.015). CONCLUSION: Consecutive assessment of atherosclerosis progression by CA-IMT measurement has importance for prediction of new CV events in PD patients.