PO-0734: The effect of TAB duration and pelvic RT in prostate cancers with gleason score 8-10: TROG study
Bildiriler > Özet Bildiri · 2017
Yazarlar: Gökhan Özyiğit, Hüseyin Cem Önal, Mehmet Şefik İğdem, Lütfiye Zümre Arıcan Alıcıkuş, A İribaş, MUSTAFA AKIN, Deniz YALMAN, İlknur Alsan Çetin, Melek Gamze Aksu, Banu Atalar, Hidayet Fazilet Dinçbaş, B Aydın, Fatma YAVAŞ, ÇİĞDEM YILDIRIM, İb Görkem, Fy Agaoğlu, Af Korcum, Serdar ÖZKÖK, Mehmet Emin Darendeliler, Hüsnü Fadıl Akyol
Radiotherapy and Oncology, Avusturya, Uluslararası, Poster, Özet Bildiri, 2017-2017, Wos, cilt 123, ss S386-S386
DOI: 10.1016/s0167-8140(17)31171-4
Özet
Purpose or ObjectiveWe performed a multi-institutional pooled data analysis as Turkish Radiation Oncology Group (TROG) to evaluate the efficacy of elective pelvic RT and TAB duration in prostate cancer patients with Gleason score (GS) of 8-10 treated with three dimensional conformal radiotherapy (3DCRT) or intensity modulated radiation therapy (IMRT). Material and MethodsA total of 641 eligible prostate adenocarcinoma patients from 11 TROG centers, treated with 3DCRT or IMRT between 1997 and 2013 were evaluated in this study.The eligibility criteria were as follows; T1-3N0M0 according to AJCC 2010 staging system, Gleason score of 8-10, a total RT dose of at least 70 Gy with 3DCRT or IMRT, at least 24 months of follow-up for all surviving patients.TAB duration, elective pelvic RT, T stage, GS, perineural invasion (PNI), total RT dose, RT technique, percent positive core biopsy (PPCB), age, and pre-biopsy PSA level were analyzed as potential prognosticators.ASTRO Phoenix definition was used for biochemical failure (PSA nadir+2 ng/dL).Log-rank test was performed for univariate analyses (UVA), and Cox-regression analysis was used for multivariate analyses (MVA). ResultsMedian follow-up was 6 years.The median prebiopsy PSA level was 21.3 ng/dL, the median TAB duration was 24 months, and the median total RT dose was 75 Gy.Fiftyone patients were died of prostate cancer, whereas 62 patient died due to other diseases.PSA failure was detected in 171 cases, and distant metastases developed in 99 patients.Five and 10 year biochemical relapse free survival (BRFS) rates for entire cohort were 76.8% and 61.1%, respectively.UVA showed that higher GS, higher PPCB, advanced T stage, PNI presence, elective pelvic RT, younger age, and higher pre-biopsy PSA level were significant poor prognostic factors for BRFS.The duration of TAB (≤12 months vs >12 months), total RT dose and RT technique did not have any significant impact on BRFS.MVA revealed that T stage (p=0.002),GS (p=0.046),age (p=0.01),PNI (p=0.04) and PPCB (p=0.001) were independent statistically significant predictors for BRFS.We did not found any significant effect of TAB duration (≤12 months vs >12 months) or elective pelvic RT on BRFS in MVA.