Evaluation of photodynamic therapy and nuclear imaging potential of subphthalocyanine integrated TiO2 nanoparticles in mammary and cervical tumor cells
Makaleler > Tam Makale · 2019
Yazarlar: Fatma YURT, Kasim Ocakoglu, Ozge Er, Hale Melis Soylu, Mine Ince, Çığır BİRAY AVCI, Cansu Caliskan Kurt, Fatma Aslihan Sari, Suleyman Gokhan Colak, Cumhur GÜNDÜZ
Journal of Porphyrins and Phthalocyanines, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2019, cilt 23, ss 908-915
DOI: 10.1142/s1088424619500639
Özet
This study, subphthalocyanines (SubPc) and SubPc integrated TiO2nanoparticles (SubPc-TiO[Formula: see text] were synthesized as novel photosensitizers. Their PDT effects were evaluated. Furthermore, nuclear imaging potential of [Formula: see text]I-labelled SubPc/SubPc-TiO2were examined in mouse mammary carcinoma (EMT6) and cervix adenocarcinoma (HeLa) cell lines. The uptake results show that SubPc labelled with [Formula: see text]I radionuclide ([Formula: see text]I-SubPc) in EMT6 and HeLa cell lines was found to be approximately the same as in the WI38 cell line. However, the uptake values of SubPc-TiO2labelled with [Formula: see text]I ([Formula: see text]I-SubPc-TiO[Formula: see text] in EMT6 and HeLa cell lines were determined to be two times higher than in the WI38 cell line. In other words, the target/non-target tissue ratio was identified as two in the EMT6 and HeLa cell lines. [Formula: see text]I-SubPc-TiO2is promising for imaging or treatment of breast and cervix tumors. In vitro photodynamic therapy studies have shown that SubPc and SubPc-TiO2are suitable agents for PDT. In addition, SubPc-TiO2has higher phototoxicity than SubPc. As a future study, in vivo experiments will be held and performed in tumor-bearing nude mice.