Investigation of the relationship of lysyl oxidases on neck metastasis and prognosis in early stage oral cavity cancers.
Makaleler > Tam Makale · 2025
Yazarlar: Vahdettin Emre Şahin, Kerem ÖZTÜRK, Göksel TURHAL, Ali VERAL
Ege Tıp Dergisi, Hakemli Üniversite Dergisi, Ulusal, Index Copernicus, 2025, cilt 64, ss 431-437
DOI: 10.19161/etd.1622224
Özet
<p>ntroduction: Cancers of the lip and tongue are the sixteenth most common malignancy worldwide, with 377,713 new cases per year. Despite the decrease in smoking, early diagnosis, and advances in adjuvant treatment methods, significant increases in tongue cancers incidence are observed in western society, especially in young adults. This study aims to investigate the effect of LOX and LOXL-2 expression in tumor cells of patients operated on for early-stage T1-T2 tongue cancer on neck metastasis and prognosis.</p><p><br></p><p>Methods: A total of 43 patients, 22 N(+) and 21 N(-) operated for T1-T2 tongue cancer were included in the study. He sought to discover cytoplasmic level LOX and LOXL-2 in the paraffin sections of subjects. The relationship of LOX and LOXL-2 cases with tumor T stage, N stage, recurrence, and survival outcomes were analyzed.</p><p>Results: A total of 43 patients, 22 N(+) and 21 N(-) operated for T1-T2 tongue cancer were included in the study. LOX expression was observed in 16 patients (n=43, 37.2%) (12 N(+) and 4 N(-)) and in 15 patients (n=43, 34.8%) (12N(+) and 3 N(-) )) LOXL-2 expression was detected. In the analysis performed according to LOX and LOXL-2 expression, it was determined that LOX and LOXL-2 expression was statistically significantly higher in the group with tumor stage T1 than in those with T2 and in the N(+) group with pathological lymph nodes in the neck compared to those with N(-) (p <0.05).</p><p>The cytoplasmic staining rate of LOX and LOXL-2 expression in neoplastic cells was found to be statistically significantly higher in patients with recurrence (p <0.05).</p><p>Conclusion: In our study, high LOX and LOXL-2 expression has been shown to have a statistically significant effect on regional recurrence, neck lymph node metastasis, and survival time. Our study will guide researchers in terms of both the development of new targeted biological agents and the creation of individualized follow-up and treatment protocols.</p>