Contrasting effects of ATP and adenosine on capsaicin challenge in asthmatic patients
Articles > Article · 2017
Authors: Özen KAÇMAZ BAŞOĞLU, Amir Pelleg, Sergei A. Kharitonov, Peter J. Barnes
Pulmonary Pharmacology & Therapeutics, Journal Indexed in SCI Expanded, International, WoS, 2017, vol 45, pp 13-18
DOI: 10.1016/j.pupt.2017.04.004
Summary
Background: Adenosine 5'-triphosphate (ATP) stimulates pulmonary vagal slow conducting C-fibres and fast conducting A delta-fibres with rapidly adapting receptors (RARs). Pulmonary C-fibres but not RARs are also sensitive to capsaicin, a potent tussigenic agent in humans. Thus, the aim of this study was to determine the effects of ATP and its metabolite adenosine (given as adenosine 5'-monophosphate, AMP) on capsaicin challenge in asthmatic patients.