Laminar distribution of the cells of origin of the spinocerebral pathways involved in nociceptive transmission and pain modulation in the rat
Makaleler > Tam Makale · 1996
Yazarlar: Gülgün ŞENGÜL, NI Hariri, F Govsa, B Erdem, G Peker, VA Maiskii
NEUROPHYSIOLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 1996, cilt 28, ss 111-118
DOI: 10.1007/bf02262771
Özet
The laminar distribution of spinomesencephalic, spinothalamic, and spinotelencephalic tract neurons, and the pattern of axonal collateralization in these spinocerebral pathways were studied In the rat by means of retrograde double-labelling of the cells with fluorescent dyes Fluoro-Gold and Primuline O. We found that sources of spinocerebral pathways to the analgesic brainstem centers, as well to the nucl. accumbens and septal nuclei, were mixed together In the marginal zone (lamina I, by Rexed), in the deep dorsal horn (laminae IV-VI), In the area around the central canal (lamina X), and within the lateral spinal nucleus. At the same time, all the above pathways retain their own specific projection fields. Thus, these spinocerebral projections could be characterized as extensive, but not diffuse. We propose that the main effect of activation of the direct spinal Inputs to the limbic system is an increase in nociceptive sensitivity, but not a suppression of nociceptive transmission at the the spinal cord level.