Biotransformation of Cycloastragenol by Cunninghamella blakesleeana NRRL 1369 Resulting in a Novel Framework
Articles > Article · 2010
Authors: Melis Kuban, Gaye ÖNGEN ÖZGEN, ERDAL BEDİR
ORGANIC LETTERS, Journal Indexed in SCI Expanded, International, 2010, vol 12, pp 4252-4255
DOI: 10.1021/ol101642a
Summary
The microbial transformation of cycloastragenol by the fungus Cunninghamella blakesleeana NRRL 1369 was investigated. Unlike the original compound, the metabolite was found to possess an interesting triterpenic skeleton derived via an exceptional transformation involving ring cleavage and methyl group migration. The structure of the new metabolite was elucidated by 1-D ((1)H, (13)C) and 2-D NMR (COSY, HMBC, HMQC, NOESY) techniques and MS analyses.