Primary evaluation of a nickel-chlorophyll derivative as a multimodality agent for tumor imaging and photodynamic therapy
Makaleler > Tam Makale · 2015
Yazarlar: Ozge Er, Fatma YURT, Kasim Ocakoglu, Cagla Kayabasi, Cumhur GÜNDÜZ
Journal of Radioanalytical and Nuclear Chemistry, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2015, cilt 306, ss 155-163
DOI: 10.1007/s10967-015-4081-x
Özet
In this study, the biological potential of a nickel chlorophyll derivative (Ni-PH-A) as a multimodal agent for tumor imaging and photodynamic therapy (PDT) was investigated. Optimum conditions of labeling with I-131 were investigated and determined as pH 10 and 1 mg amount of iodogen. Biodistribution results of I-131 labeled Ni-PH-A in female rats indicated that radiolabeled Ni-PH-A maximum uptake in the liver, spleen and ovary was observed at 30 min. Intercellular uptake and PDT efficacy of Ni-PH-A were better in MDAH-2774 (human ovarian endometrioid adenocarcinoma) than in MCF-7 (human breast adenocarcinoma) cells. Ni-PH-A might be a promising multimodal agent for lung, ovary and liver tumor imaging and PDT.