Tissue Engineering Based on the Importance of Collaboration Between Clinicians and Basic Scientists Regarding Mesenchymal Stromal Cells
Kitapta bölümler > Diğer · 2012
Yazarlar: Aysel Yurtsever
Adult and Embryonic Stem Cells, Diğer, Humana Press, B, Uluslararası, 2012, ss 69-80, ,
DOI: 10.1007/978-1-61779-630-2_7
Özet
Tissue engineering is an interdisciplinary field that applies the principles of biology and engineering to developing tissue substitutes to restore, maintain, or improve the function of diseased or damaged human tissues. Autologous mesenchymal stromal cells (MSCs) are good candidates for tissue engineering and regenerative medicine in that they can replace damaged tissues in the human body owing to their self-renewal, plasticity, engraftment, and homing capacity. MSCs can easily differentiate into adipocytes, osteoblasts, and fibroblasts using various transcription factors and hormones. For cell treatments, nanotechnological scaffolds in various structures are needed for differentiation of stem cells. Biodegradable polymeric constructs for bone tissue engineering, are three-dimensional structures that allow bone cells to attach and reproduce on them. Because of biodegradability properties, they are not permanent in the body and are degraded slowly while bone cells are reproducing. Thus, bone cells replace the scaffold in time, which means healing of the defective site. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.