The 4A Syndrome Association with Osteoporosis.
Makaleler > Tam Makale · 1999
Yazarlar: A. GÖKHAN ÖZGEN, ERTUGRUL ERCAN, ÖMER ÖZÜTEMIZ, FÜSUN HAMULU, FIRAT BAYRAKTAR, CANDEGER YILMAZ
Endocrine Journal, Uluslararası, Wos, 1999, cilt 46, ss 227-230
Özet
4A syndrome is characterised by adrenocortical insufficiency, achalasia, alacrima, autonomic and other neurological abnormalities. We report an 18-year-old boy with 4 A syndrome and having all classical features of the disease including sensorimotor neuropathy. In addition, the patient had low aldosterone levels and signs of osteoporosis, which apparently developed without glucocorticoid replacement therapy. Although it is speculated that the lack of local growth factors, nutritional deficiency secondary to achalasia or receptor abnormalities regarding bone metabolism contribute to osteoporosis, its etiopathogenesis still needs to be clarified.