Mitosis and apoptosis in canine cutaneous histiocytoma and transmissible venereal tumour
Articles > Article · 2002
Authors: T Guvenc, MEHMET HALIGÜR, Mehmet Nurullah ORMAN, R Haziroglu
ACTA VETERINARIA HUNGARICA, Journal Indexed in SCI Expanded, International, 2002, vol 50, pp 315-321
Summary
Cell proliferation and apoptosis in canine cutaneous histiocytomas and transmissible venereal tumours were examined in twenty cases. The Ki-67 immunohistochemistry and Tunel methods were used to detect mitotic activity and apoptosis, respectively. The number of Ki-67 imimmoreactive cells was 11.65 (+/- 1.1706) in canine cutaneous histiocytomas and 17 (+/- 2.1751) in transmissible venereal tumours. The mean values of apoptotic cells for canine cutaneous histiocytomas and transmissible venereal tumours were 13.25 (+/- 1.8758) and 8.52 (+/- 1.1007), respectively. It was considered that mitotic activity and apoptotic indices were useful in differentiation of canine cutaneous histiocytomas and transmissible venereal tumours. The correlation values for canine cutaneous histiocytomas and transmissible venereal tumours were 0.359 (+/- 0.330) and -0.232 (+/- 0.344), respectively. No significant (P>0.05) correlation was found between mitosis and apoptosis in these two tumour types.