Enhancement of taxane-induced cytotoxicity and apoptosis by gossypol in human breast cancer cell line MCF-7
Articles > Article · 2009
Authors: Betül KARACA, H. Atmaca, S. Uzunoglu, BÜLENT KARABULUT, Ulus Ali ŞANLI, RÜÇHAN USLU
JOURNAL OF BUON, Journal Indexed in SCI Expanded, International, 2009, vol 14, pp 479-485
Summary
Purpose: Gossypol is a natural polyphenolic compound extracted from cotton plant (Gossypium species) which has shown potent inhibitory effect on cell growth of many types of cancers. In this study, we aimed to evaluate the interaction of gossypol with some conventional drugs known to be effective in the treatment of breast cancer like taxanes, doxorubicin, gemcitabine, cisplatin and vinorelbine, in MCF-7 breast cancer cells.