Different doses of radiation on agar colony forming development in C6 glioma cells: Assessment by thymidine labeling index, and bromodeoxyuridine labeling index
Articles > Article · 2007
Authors: Tolga Ozmen, Gülperi ÖKTEM, Sevilcan Tuna, Burcu Biltekin, Secnur Denir, Ayhan Bilir
TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, Journal Indexed in SCI Expanded, International, 2007, vol 27, pp 321-327
Summary
Objective: Gliomas are relatively frequent in adults, and are among the most malignant primary brain tumors. Glioblastoma. multiforme, like many other tumors that exhibit radiation sensitivity in vitro, seems to be very resistant to radiation in vivo, thus suggesting that irradiation may not be a rate-limiting factor for malignant glioma tumor growth. In this study, we aimed to determine the optimal dose of radiation in C6 glioma colony forming assay, which is a valuable tool for antitumor treatment screening.