Sepsis-induced changes in behavioral stereotypy in rats; involvement of tumor necrosis factor-alpha, oxidative stress, and dopamine turnover
Makaleler > Tam Makale · 2013
Yazarlar: Oytun ERBAŞ, Dilek TAŞKIRAN
Journal of Surgical Research, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2013, cilt 186, ss 262-268
DOI: 10.1016/j.jss.2013.08.001
Özet
Background: Sepsis-associated encephalopathy (SAE) is defined as a diffuse or multifocal cerebral dysfunction that generally occurs early during severe sepsis. The complete pathophysiology of SAE is unknown, but several mechanisms including endotoxins, inflammatory mediators, the alteration of amino acids and of neurotransmitters, apoptosis, oxidative stress, and blood-brain barrier dysfunction have been suggested. The aim of the present study was to explore the relationship between behavioral stereotypy and plasma levels of tumor necrosis factor-alpha (TNF-alpha) and malondialdehyde (a marker of lipid peroxidation), and brain homovanillic acid content (a marker of dopamine turnover) in a surgically induced sepsis model in rats.