The Disappearing Brain-Sparing Effect in Early-Onset Fetal Growth Restriction Fetuses Revisited
Makaleler > Tam Makale · 2013
Yazarlar: Ahmet Özgür YENİEL, Ahmet Mete ERGENOĞLU, Cem Y. SANHAL, Ali AKDEMİR, Fuat AKERCAN, Mert KAZANDI, Sermet SAĞOL
FETAL DIAGNOSIS AND THERAPY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2013, cilt 36, ss 166-172
DOI: 10.1159/000355933
Özet
Objective: To evaluate the association between the brain-sparing situation and perinatal outcomes in fetuses with early-onset fetal growth restriction (EO-FGR) with absent or reverse end-diastolic flow in the umbilical artery (UA A/REDF). Methods: We evaluated fetuses with EO-FGR who had patterns of UA A/REDF without abnormal venous Doppler indices. Participants were divided into two groups according to measurements of mid-cerebral artery pulsatility index (MCA PI) just before delivery. Group 1 (n = 45) included those with a brain-sparing effect (BSE) (a MCA PI <5th percentile for the gestational age) and group 2 (n = 14) included those with a disappearing BSE, defined as an MCA PI increase towards normal values after the BSE detected at the initial evaluation. Short-term perinatal outcomes were analyzed. Results: Compared to group 1, group 2 had a significantly low birth weight (p = 0.018) and high rates of extended neonatal intensive care unit hospitalization (p = 0.049 respectively). Conclusion: On the basis of longitudinal measurements of MCA PI, increases after the reduction <5th percentile might be related to poor perinatal outcomes in fetuses with EO-FGR who had UA A/REDF without abnormal venous flow patterns. (C) 2013 S. Karger AG, Basel