Clinical Contribution of Next-Generation Sequencing Multigene Panel Testing for BRCA Negative High-Risk Patients With Breast Cancer
Makaleler > Tam Makale · 2021
Yazarlar: Aslı ECE SOLMAZ, Levent YENİAY, Erhan GÖKMEN, Osman ZEKİOĞLU, AYFER HAYDAROĞLU, IŞIL GÜNHAN BİLGEN, Feriştah Ferda ÖZKINAY, HÜSEYİN ONAY
Clinical Breast Cancer, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2021, cilt 21, ss e647-e653
DOI: 10.1016/j.clbc.2021.04.002
Özet
Next-generation sequencing has increased the detection of pathogenic/likely pathogenic variants in genes other than BRCA1/2. This study included 188 high-risk patients with BRCA1/2-negative breast cancer tested with a multigene cancer panel. Among 188 proband cases, 18 variants in 21 patients (11.1%) were classified as pathogenic/likely pathogenic. A multigene panel increased the diagnosis success in patients with BRCA1/2-negative high-risk breast cancer.