Comparative Evaluation of Release Profiles from Hydrogel, Oleogel, and Bigel Systems Containing Model Radiopharmaceuticals for Buccal Delivery
Articles > Article · 2025
Authors: Meliha GÜNEŞ, Meliha EKİNCİ, Derya İLEM ÖZDEMİR, Sinem Yaprak KARAVANA
ACS OMEGA, Journal Indexed in SCI Expanded, International, Scopus, 2025, vol 10, pp 62554-62562
DOI: http://doi.org/10.1021/acsomega.5c06182
Summary
<p>This study presents a comparative evaluation of hydrogel, Oleogel, and bigel formulations incorporating model radiopharmaceuticals�[99mTc]Tc-DTPA (hydrophilic) and [99mTc]Tc-HMPAO (lipophilic)�for potential buccal drug delivery applications. The gels were characterized in terms of rheological behavior, mechanical properties, and mucoadhesivestrengthtoassesstheirsuitabilityformucosaladministration.In vitropermeationstudiesusingFranzdiffusioncellswithsyntheticmembranes wereperformedtoevaluatethereleaseprofilesoftheradiolabeledcompounds. The findings demonstrated that bigel formulations exhibited the most favorablemechanical and viscoelastic properties, superior release for both hydrophilicand lipophilicagents, andenhancedmucoadhesiveperformance compared tohydrogel andOleogel systems.Oleogels, while showinggood adhesiveness,were less effective indrug release, particularly forhydrophilic compounds.Hydrogelsdisplayedhighmucoadhesionbut limitedrelease for lipophilic drugs. The biphasic nature of bigels provided a versatilematrix capable of optimizing the delivery of diverse radiopharmaceuticals throughthebuccal route.</p>