Synthesis of α-Alkylated Ketones via Selective Epoxide Opening/Alkylation Reactions with Primary Alcohols
Makaleler > Tam Makale · 2021
Yazarlar: Sertac Genc, Süleyman GÜLCEMAL, Salih GÜNNAZ, BEKİR ÇETİNKAYA, Derya GÜLCEMAL
Organic Letters, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2021, cilt 23, ss 5229-5234
DOI: 10.1021/acs.orglett.1c01765
Özet
A new method for converting terminal epoxides and primary alcohols into α-alkylated ketones under borrowing hydrogen conditions is reported. The procedure involves a one-pot epoxide ring opening and alkylation via primary alcohols in the presence of an N-heterocyclic carbene iridium(I) catalyst, under aerobic conditions, with water as the side product.