CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response
Makaleler > Tam Makale · 2020
Yazarlar: SK Bromley, Hasan AKBABA, V Mani, R Mora-Buch, AY Chasse, A Sama, AD Luster
Cell Reports, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2020, cilt 32, ss 108085-108085
DOI: 10.1016/j.celrep.2020.108085
Özet
CD8 + tissue-resident memory T cells (T RM ) persist at sites of previous infection, where they provide rapid local protection against pathogen challenge. CD8 + T RM expressing the α1 chain (CD49a) of integrin VLA-1 have been identified within sites of resolved skin infection and in vitiligo lesions. We demonstrate that CD49a is expressed early following T cell activation in vivo , and TGF-β and IL-12 induce CD49a expression by CD8 + T cells in vitro . Despite this rapid expression, CD49a is not required for the generation of a primary CD8 + T cell response to cutaneous herpes simplex virus (HSV) infection, migration of CD8 + T cells across the epidermal basement membrane, or positioning of T RM within basal epidermis. Rather, CD49a supports CD8 + T RM persistence within skin, regulates epidermal CD8 + T RM dendritic extensions, and increases the frequency of IFN-γ + CD8 + T RM following local antigen challenge. Our results suggest that CD49a promotes optimal cutaneous CD8 + T RM -mediated immunity.